Our laboratory is interested in  the mechanisms that the aging brain utilizes to learn and how the aging brain handles the information that it receives from the environment. We think that the aged brain is not able to maintain the contacts between brain cells that facilitate the transmission of information and the formation of memories. This inability of maintaining the contacts between brain cells may be one of the reasons why the aging brain shows deficits learning and remembering. The laboratory is also interested in knowing how after a stroke the brain is sometimes able to compensate for the loss of brain cells and some post-stroke patients are able to recover brain functionalities that were damaged during the stroke. Understanding these mechanisms will help in the design of therapeutic approaches to improve the quality of life of the elderly and of those recovering after stroke.

In addition, we are addressing a very important research line, how does gender influence the brain? Does the estrous cycle affect the formation and evolution of synaptic contacts in the cortex? Are cortical dynamics stable across the estrous cycle? Are the mechanisms regulating memory and learning enhanced or impaired in the cortex at specific stages of the cycle? We are trying to answer these questions using our in vivo imaging approach.

© Mostany Lab | Department of Pharmacology | Tulane University School of Medicine | 1430 Tulane Avenue, New Orleans, LA 70112